Abstract This study aimed to determine the phytochemical components, microbial inhibitory effectiveness and antioxidant properties of Aerva lanata plant extracts. The whole plant showed various medicinal applications in folklore and traditional medicine in various parts of the world. The organic extracts such as ethanol, ethyl acetate, chloroform, acetone, water and methanol were subjected for various phytochemical analysis and confirmed for the existence of flavonoids, glycosides, terpenoids and alkaloid containing components. Alternatively, the extracts were performed for the antibacterial activities against the microbial pathogens and antioxidant properties. Results indicated that, the solvent extracts showed prominent activity against the tested strains. The plant extract was highly effective against E.
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E-mail: moc. This article has been cited by other articles in PMC. Abstract Context: Aerva lanata is not prescribed for long-term use in Ayurveda as it is believed to produce structural changes in the urinary tract of the patients leading to renal failure.
Aim: To investigate the toxic effects of Aerva lanata on the structure and function of urinary tract of a rat model Sprague-Dawley rats. Settings and Design: An experimental study. Thirty male and thirty female healthy rats were randomly assigned to three groups test groups 1, 2 and control and administered dried infusion of A.
Materials and Methods: Blood and urine were collected and creatinine was measured. Creatinine clearance Ccr and urine flow rate UFR of rats were determined to assess renal function. Kidneys, ureters, and bladders of rats were harvested for light microscopic LM studies. Electron microscopic EM studies were done on kidney tissues.
Statistical Analysis Used: Difference in mean values of Ccr and UFR between test groups and the control group were compared statistically using independent T test.
LM and EM findings of the two treated groups T1 and T2 were statistically compared with the control group C using standard normal distribution. Results: Ccr and UFR of test groups were not significantly different from that of the control group.
LM studies did not show any histological changes suggesting toxicity. EM, however showed significant ultra structural changes in proximal convoluted tubular epithelial cells of rats in the two test groups.
Conclusion: Administration of dried Aerva lanata for a period of one month did not produce significant effects on renal function of rats. However administration for the same period caused significant ultra structural changes in the proximal convoluted tubular epithelial cells.
It is widely spread in the drier parts of the tropics and the sub tropics of the world. Aerva lanata is commonly described in Ayurveda as a diuretic with anti-inflammatory, antihelmintic, anti-bacterial and mild analgesic effects. It is used in the treatment of lithiasis, cough, asthma, and headache and as an antidote for rat poisoning.
It is believed that long-term ingestion of Aerva lanata is harmful, as it has adverse effects on the urinary tract. Alkaloids, terpenoids, sterols, several flavonoid glycosides and polyphenols had been isolated from Aerva lanata by researchers in Russia and India.
They concluded that Aerva lanata does not produce diuresis, natriuresis, kaliuresis or change in urinary osmolar output. Findings showed there was no statistically significant reduction in renal function as measured by creatinine clearance after administering two doses of dried and fresh Aerva lanata daily for a period of one month. There were no significant histological changes detected by light microscopy in the kidneys, bladder and ureters of rats fed with Aerva lanata for one month. An ultra structural evaluation has not been performed.
Aerva lanata is not prescribed for more than a week in ayurveda medicine, in keeping with the general belief of producing structural changes in the urinary tract leading to renal failure. However as this is not scientifically proven, people continue to self medicate themselves with Aerva lanata. To determine whether long-term administration of Aerva lanata produces toxic effects on the renal function and structure, an experimental study was designed on a rat model based on the guidelines set by the world health organization WHO.
Thirty males and thirty females were housed in cages in the animal house under tropical laboratory conditions and were provided with a standard laboratory diet and water. Plant material and sample preparation Whole plants of Aerva lanata were purchased from a single herb plant supplier in the Colombo city.
Botanical identity of the plant was determined by the principal investigator using herbarium specimens. The dried form also produced more diuretic activity than the fresh form in the preliminary investigation carried out by Herath et al.
Aerva lanata drink infusion was prepared using dried herb in ml of hot water. The herb was steeped for 15 min and then the infusion was strained. According to WHO criteria, several doses should be used to study the long-term toxic effects of an herb. Solution 1 - infusion of A. Experiment on effects of long-term use of Aerva lanata Baseline measurements of urine output for 5 days and creatinine clearance for 3 days were obtained prior to starting the experiment by collecting 24 h urine and 0.
Sixty rats were randomly divided into three groups. Each group consisted of an equal number of male and female rats. On the 30th day of the experiment, rats were kept separately in metabolic cages and urine was collected for 24 h. On the 31st day, 0. Serum and urine samples were obtained to determine the creatinine clearance Ccr of each rat.
Effects on water consumption Water consumption of each rat was measured on a daily basis during the baseline period and on the 30th day of the study. Effects on renal structure On the 31st day of the experiment, rats were anesthetized by ether. The animals were dissected through a mid-ventral laparotomy to harvest kidneys, ureters and bladder. The animals were sacrificed by cardiac puncture after harvesting the organs.
Paraffin sections were made from fixed tissues after tissue processing. Only thirty animals were selected by simple random sampling for electron microscopic evaluation. Difference in mean values of Ccr and UFR between the final samples and baseline samples in test groups and the control group were considered for the statistical comparison.
Statistical comparisons were done using the SPSS computer package version 15 and independent T test was used for comparison. Corresponding LM findings of kidney samples of the rats randomly selected for EM studies and the EM findings were expressed as percentages in each group.
The two treated groups T1 and T2 were then statistically compared with the control group C using standard normal distribution SND. However, there is a marked reduction in the Ccr in T1 compared to the control.
8 Top Medicianl Uses of Aerva Lanta | Polpala (Cherula | Sirupeelai)
Take 10 drops in a glass of water, morning and evening. Take this for a month 2. Varuna Crataeva Nurvala , take 1 capsule mg once a day, use it for a month. Shatavari Asparagus Racemosus. Take one capsule morning evening. Take Punarnava in its water extract form for a month. Repeat the process for one month and study the results.
Australasia : Queensland  Uses The plant is said to be diuretic and demulcent. Its diuretic action is said to be very effective in the treatment of urethral discharges and gonorrhoea and is of value in cases of lithiasis and as an anthelmintic. A trace of alkaloid has been detected. Food The whole plant, especially the leaves, is edible. The leaves are put into soup or eaten as a spinach or as a vegetable. The plant provides grazing for stock, game in and chickens. Medicinal Leaves A leaf-decoction is prepared as a gargle for treating sore-throat and used in various complex treatments against guinea-worm.
Aerva Lanata Herb Uses, Benefits, Cures, Side Effects, Nutrients